SCIENTIFIC PUBLICATIONS AND POSTERS

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Poster: Identification of Specific EEG Biomarkers in Aged Mice

This new analysis pipeline provides a tool to more quickly and objectively assess the effects of compounds in development and compare them to existing reference drugs for various indications.

Poster: Standardized Pharmaco-Sleep-Electroencephalography as a Preclinical Tool for Antidepressant Drug Profiling

We evaluated the possibility to employ a Machine Learning approach to assess the dose-dependency of antidepressants, with distinct mechanisms of action: fluoxetine and maprotiline in wild-type C57BL/6 mice.

Poster: Assessing Sleep Architecture and Pharmacodynamics: An EEG-Based Platform for Drug Testing

This new analysis pipeline provides a tool to more quickly and objectively assess the effects of compounds in development and compare them to existing reference drugs for various indications.

Publication: Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy

Focal Epilepsy

Publication: Pronounced Antiepileptic Activity of the Subtype-Selective GABAA -Positive Allosteric Modulator PF-06372865 in the GAERS Absence Epilepsy Model

Generalized Absence Epilepsy.
A joint publication SynapCell x Pfizer.

Publication: BAER-101, a selective potentiator of α2- and α3-containing GABAA receptors, fully suppresses spontaneous cortical spike-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)

Generalized Absence Epilepsy.

Poster: Improving Drug Discovery in Parkinson’s Disease Using Brain Oscillations as Translational Biomarkers

We investigate the use of aberrant cortical oscillations as translational biomarkers for Parkinson’s Disease Drug development and evaluate the effect of acute (L-Dopa, Apomorphine) and …

Poster: Pronounced Antiepileptic Activity of the Subtype-Selective GABAA Positive Alosteric Modulator PF-06372865 in the GAERS Model

Assessing the antiepileptic effect of PF-06372865, a newly developed GABAA modulator, developed by Pfizer, in a preclinical model of absence seizures, the GAERS rat.

Poster: The SynapCell MTLE Model, a Predictive Model of Focal Epilepsy for Drug Discovery

A powerful preclinical tool accelerating drug-resistant epilepsy research. This MTLE model accurately mirrors human focal Epilepsy capturing drug sensitivities and crucial EEG biomarkers.

Poster: The Amygdala-Kindling Model, High-Performance Platform to Accelerate the Identification of Novel Anti-Seizure Medications

This study intends to highlight translational and predictive aspects of the amygdala-kindling model as a potential asset for characterizing new entities with improved tolerability and efficacy.